Phatcharida Jantaree, Ph.D.
Contact Information
Phatcharida Jantaree, Ph.D.
Email : phatcharida.j@cmu.ac.th
Address : Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), 9th floor – The 50th Anniversary Building, Faculty of medicine, Chiang Mai University
Research Interests
My research focuses on conducting functional genetic and epigenetic studies to gain valuable insights into the implications of rare genetic variants in neurological function and associated diseases. The primary objective is to shed light on the underlying mechanisms of neurological disorders linked to these rare genetic variants, ultimately paving the way for the development of targeted therapeutic interventions. In addition, my research endeavors encompass the establishment of novel disease-specific models through stem cell research, including the utilization of induced pluripotent stem cells (iPSCs), organoids, 3D in vitro models, and organ-on-chip models. These cutting-edge models are integral to our research scope as they enable us to faithfully replicate disease conditions in a controlled laboratory setting, facilitating the investigation of disease mechanisms and the development of novel therapeutic approaches.
Expertise
- Biochemistry and molecular biology
- Cell biology
- Organoids and Organ–on–chip models
Biography
Education
Ph.D. : 2018 – 2023
Doctor of Natural Sciences (Molecular Biology) Otto von Guericke University Magdeburg, Germany Research training group (RTG) 2408: Maladaptive processes across physiological barriers in chronic diseases (funded by Deutsche Forschungsgemeinschaft (DFG), Germany)
Thesis : Role of USP48 and A20 on cell survival of gastric epithelium during Helicobacter pylori infection
Supervisor : Prof. Dr. rer. nat. Michael Naumann
M.Sc. : 2012 – 2016
Master of Science in Applied Biological Sciences (International Program) Chulabhorn Graduate Institute, Bangkok, Thailand
Thesis : Modulation of the metastatic potential of human hepatocellular carcinoma cells by an environmental contaminant and natural products
Supervisor : Emeritus Prof. Dr. M.R. Jisnuson Svasti
Co-supervisor : Dr. Kriengsak Lirdprapamongkol
B.S. : 2008 – 2012
Bachelor of Science in Biochemistry and Biochemical Technology Chiang Mai University, Chiang Mai, Thailand
Thesis : Evaluation and comparison of antioxidant activities and total phenolic compounds of homemade and commercial fermented vinegars
Advisor : Asst. Prof. Dr. Nopakarn Chandet
Awards
2016 :
Outstanding poster presentation award at the 5th International Biochemistry and Molecular Biology Conference, Songkhla, Thailand
2012 :
The best oral presentation award at Academic Congress, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand
2010 :
Academic outstanding award from Faculty of Science, Chiang Mai University, Chiang Mai, Thailand
2010 :
Young Thai science ambassador from National Science Museum, Bangkok, Thailand
Research & Publications
Research Interests
My research focuses on conducting functional genetic and epigenetic studies to gain valuable insights into the implications of rare genetic variants in neurological function and associated diseases. The primary objective is to shed light on the underlying mechanisms of neurological disorders linked to these rare genetic variants, ultimately paving the way for the development of targeted therapeutic interventions. In addition, my research endeavors encompass the establishment of novel disease–specific models through stem cell research, including the utilization of induced pluripotent stem cells (iPSCs), organoids, 3D in vitro models, and organ–on–chip models. These cutting–edge models are integral to our research scope as they enable us to faithfully replicate disease conditions in a controlled laboratory setting, facilitating the investigation of disease mechanisms and the development of novel therapeutic approaches.
Publications
- Lim MCC, Jantaree P, & Naumann M (2023). The conundrum of Helicobacter pylori-associated apoptosis in gastric cancer. Trends in cancer, S2405-8033(23)00080-8. Advance online publication. https://doi.org/10.1016/j.trecan.2023.04.012
- Jantaree P, Yu Y, Chaithongyot S, Täger C, Sarabi M A, Meyer T F, Boccellato F, Maubach G, Naumann M (2022) Human gastric fibroblasts ameliorate A20-dependent cell survival in co-cultured gastric epithelial cells infected by Helicobacter pylori. Biochimica et Biophysica Acta. Molecular Cell Research, 1869(12), 119364.DOI: 10.1016/j.bbamcr.2022.119364
- Jantaree P, Chaithongyot S, Sokolova O, Naumann M (2022) USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection. Cellular and Molecular Life Sciences, 79(8):461. DOI: 10.1007/s00018-022-04489-7.
- Noack L, Xu B, Bundkirchen K, Zhou Y, Köhler K, Jantaree P, Neunaber C, Nowak A, Relja B (2022) Acute intoxication with alcohol reduces trauma-induced proinflammatory response and barrier breakdown in the lung via Wnt/ß-catenin signaling pathway.Frontiers in Immunology, 13:866925. DOI: 10.3389/fimmu.2022.866925.
- Bakhchova L*, Jantaree P*, Gupta A, Isermann B, Steinmann U, Naumann M (2021) On-a-chip-based sensitive detection of drug-induced apoptosis in polarized gastric epithelial cells. ACS Biomaterials Science and Engineering, 7(12):5474–5483. DOI: 10.1021/acsbiomaterials.1c01094. * shared first authorship
- Chaithongyot S, Jantaree P, Sokolova O, Naumann M (2021) NF-B in gastric cancer development and therapy. Biomedicines, 9(8):870. DOI: 10.3390/biomedicines9080870.
- Jantaree P, Bakhchova L, Steinmann U, Naumann M (2021) From 3D back to 2D monolayer stomach organoids-on-a-chip. Trends in Biotechnology, 39(8):745–748. DOI: 10.1016/j.tibtech.2020.11.013.
- Prangsaengtong O, Jantaree P, Lirdprapamongkol K, Ngiwsara L, Svasti J, Koizumi K (2018) Aspirin suppresses components of lymphangiogenesis and lymphatic vessel remodeling by inhibiting the NF-B/VCAM-1 pathway in human lymphatic endothelial cells. Vascular Medicine (United Kingdom), 23(3):201–211. DOI: 10.1177/1358863X18760718.
- Prangsaengtong O, Jantaree P, Lirdprapamongkol K, Svasti J, Koizumi K (2018) Shikonin suppresses lymphangiogenesis via NF-B/HIF-1 axis inhibition. Biological and Pharmaceutical Bulletin, 41(11):1659–1666. DOI: 10.1248/bpb.b18-00329.
- Jantaree P, Lirdprapamongkol K, Kaewsri W, Thongsornkleeb C, Choowongkomon K, Atjanasuppat K, Ruchirawat S, Svasti J (2017) Homodimers of vanillin and apocynin decrease the metastatic potential of human cancer cells by inhibiting the FAK/PI3K/Akt signaling pathway. Journal of Agricultural and Food Chemistry, 65(11):2299–2306. DOI: 10.1021/acs.jafc.6b05697.
- Atjanasuppat K, Lirdprapamongkol K, Jantaree P, Svasti J (2015) Non-adherent culture induces paclitaxel resistance in H460 lung cancer cells via ERK-mediated up-regulation of βIV-tubulin. Biochemical and Biophysical Research Communications, 466(3):493–498. DOI: 10.1016/j.bbrc.2015.09.057.