• Integrating liquid biopsy analysis for advanced non-invasive cancer diagnosis and management; Characterization of circulating tumour cell undergoing epithelial mesenchymal transition and its molecular heterogeneity in Hepatocellular carcinoma
• Single-cell transcriptome analysis characterizes circulating tumour cell in osteosarcoma
• Establishment Thailand’s Single-Cell Omics: Technologies platform development for precision medicine towards the international Human Cell Atlas consortium

Research Interests

• Liquid biopsy
• Circulating tumor cells (CTCs)
• CTCs subtypes Single-cell sequencing technology
• Single-cell omics Cancer biology

Publications

1. Moonmuang S, Tantraworasin A, Orrapin S, Udomruk S, Chewaskulyong B, Pruksakorn D, Chaiyawat P. The Role of Proteomics and Phosphoproteomics in the Discovery of Therapeutic Targets and Biomarkers in Acquired EGFR-TKI-Resistant Non- Small Cell Lung Cancer. Int. J. Mol. Sci. 2023, 24, 4827.
2. Udomruk S, Phanphaisarn A, Kanthawang T, Sangphukieo A, Sutthitthasakul S, Tongjai S, Teeyakasem P, Thongkumkoon P, Orrapin S, Moonmuang S, Klangjorhor J, Pasena A, Suksakit P, Dissook S, Puranachot P, Settakorn J, Pusadee T, Pruksakorn D, Chaiyawat P. Characterization of Cell-free DNA Size Distribution in Osteosarcoma Patients. Clin Cancer Res. 2023:CCR-22-2912.
3. Orrapin S, Udomruk S, Lapisatepun W, Moonmuang S, Phanphaisarn A, Phinyo P, Pruksakorn D, Chaiyawat P. Clinical Implication of Circulating Tumor Cells Expressing Epithelial Mesenchymal Transition (EMT) and Cancer Stem Cell (CSC) Markers and Their Perspective in HCC: A Systematic Review. Cancers (Basel). 2022;14:3373. doi: 10.3390/cancers14143373.
4. Klangjorhor J, Pongnikorn D, Phanphaisarn A, Chaiyawat P, Teeyakasem P, Suksakit P, Pasena A, Udomruk S, Orrapin, S, Pornwattanavate S, Waisri N, Daoprasert K, Wisanuyotin T, Santong C, Sangrajrang S, Sitthikong S, Tuntarattanapong P, Prechawittayakul P, Pruksakorn D. An analysis of the incidence and survival rates of bone sarcoma patients in thailand: reports from population- based cancer registries 2001–2015. Cancer Epidemiology 2022, 76, 102056.
5. Orrapin S, Roytrakul S, Phaonakrop N, Thaisakun S, Tragoolpua K, Intorasoot A, McGill S, Burchmore R, Intorasoot S. Fungicidal Activity of Recombinant Javanicin against Cryptococcus neoformans Is Associated with Intracellular Target(s) Involved in Carbohydrate and Energy Metabolic Processes. Molecules. 2021;20;26(22):7011. doi: 10.3390/molecules26227011. PMID: 34834105; PMCID: PMC8618071.
6. Udomruk S, Orrapin S, Pruksakorn D, Chaiyawat P. Size distribution of cell-free DNA in oncology. Crit Rev Oncol Hematol 2021;166:103455.
7. Orrapin S, Intorasoot A, Roytrakul S, Dechsupa N, Kantapan J, Onphat Y, et al. A novel recombinant javanicin with dual antifungal and anti-proliferative activities. Sci Rep 2019;9:18417.
8. Wanmakok M, Orrapin S, Intorasoot A, Intorasoot S. Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro. Gene 2018;671:1-9.
9. Intorasoot S, Tharinjaroen CS, Phunpae P, Butr-Indr B, Anukool U, Intachai K, Orrapin S, Apiratmateekul N, Arunothong S, Suthachai V,Saengsawang K, Khamnoi P, Pata S, Kasinrerk W, Tragoolpua K. Novel potential diagnostic test for Mycobacterium tuberculosis complex using combined immunomagnetic separation (IMS) and PCR- CTPP. J Appl Microbiol 2016;121:528-32
10. Intorasoot S, Intorasoot A, Limpaisarn S, Kojorla N, Orrapin S, Wanmakok M, Khantawa B. Loop-mediated isothermal amplification for rapid detection of Streptococcus suis in hemoculture and clinical isolates. Bull Chiang Mai Assoc Med Sci 2016;49:207-17.
11. Tharinjaroen CS, Intorasoot S, Anukool U, Phunpae P, Butr-Indr B, Orrapin S, Sangboonruang S,  Arunothong S, Chaiyasirinroj B, Kunyanone N, Kasinrerk W, Tragoolpua K, Novel targeting, lepB Gene, using polymerase chain reaction with confronting two pair primers (PCR-CTPP) for simultaneous detection of Mycobacterium tuberculosis complex and Mycobacterium bovis J Med Microbiol 2016;65:26-43.
12. Orrapin S, Intorasoot S. Recombinant expression of novel protegrin-1 dimer and LL- 37-linker-histatin-5 hybrid peptide mediated biotin carboxyl carrier protein fusion partner Protein Expr Purif 2014;93:46-53.

Address  :  9^th floor – The 50^th Anniversary Building, Faculty of Medicine, Chiang Mai University, 110 Intawaroros Road, Si Phum, Muang, Chiang Mai 50200

Email  :  santhasiri.or@cmu.ac.th

Organizations  :  Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM)