The CERT Center is Composed of Seven Research Units.

Head of Unit
Krekwit Shinlapawittayatorn
MD, PhD

Cardiac Catherization & Electrophysiology Unit

The Cardiac Electrophysiology Unit studies cardiac performance in vivo and in vitro using clinically relevant models. Defibrillation efficacy and ventricular fibrillation inducibility are studied. Cardiac performance is assessed using PV-loop measurements. Cardiac myocytes are isolated and advanced imaging techniques are used to investigate calcium transients. Patch clamp techniques are used to study membrane channel kinetics.

Head of Unit
Siriporn Chattipakorn
DDS, PhD

Neuro-Electrophysiology Unit

The Neuroelectrophysiology Unit addresses research questions focused on the brain in mice and rats. The Unit employs extracellular recording techniques and behavior assessment tools such as the Morris water maze.

Head of Unit
Wasana Pratchayasakul
PhD

Neurocardiology Unit

The Neurocardiology Unit evaluates the physiological effects of vagal nerve stimulation on heart performance under conditions of extreme stress such as ischemia reperfusion injury.

Head of Unit
Sirinart Kumfu
PhD

Molecular Biology Unit

The Molecular Biology Unit is critical to the investigation of underlying mechanisms of action in disease. Intracellular signaling pathways can be explored in detail to unravel the complexity of physiological processes. Cardiac tissues are first collected, and myocytes are isolated to evaluate the behavior of cellular components, cell membrane channels, and certain intracellular organelles, such as mitochondria. Specific instruments employing laser fluorescence imaging are used to assess mitochondrial reactive oxygen species production, swelling and membrane depolarization. Protein-level analytical methods include Western Blotting using gel electrophoresis, and biomarker assessment using ELISA and HPLC technology.

Head of Unit
Jirapas Sripetchwandee
PhD

Cell Culture / Stem Cell Unit

The Cell Culture/Stem Cell Unit uses cell systems to evaluate therapeutic strategies and the potential for cell therapy to target specific cardiovascular disorders.

Head of Unit
Chanisa Thonusin
MD, PhD

Metabolomic Unit

Quantification of the metabolite levels in the biofluids and tissues, in humans and animal models

Head of Unit
Nipon Chattipakorn
MD, PhD

Clinical Research Unit

The Clinical Research Unit studies primary cardiovascular disorders resulting from hypertension and myocardial infarction as well as cardiomyopathy secondary to severe blood disorders like thalassemia.